A number of characteristic properties of pharmaceuticals and biopharmaceuticals have been obtained by Differential Scanning Calorimetry (DSC) technique that is considered as a universal pharmaceuticals and biopharmaceuticals product development monitor. This review relates to DSC development and applications within pharmaceutical and biopharmaceuticals research areas. DSC is a rapid and accurate thermo-analytical technique for a wide variety of transitions [e.g. glass transition, detection of amorphous material in semi-crystalline compounds, melting and crystallization, purity, polymorphs, drug-excipient interaction, drug-receptor interaction, protein denaturation, freeze drying, thermal behavior of lipid bilayers and of lipidic drug delivery systems] in the pharmaceutical industry. In addition, DSC thermally characterize proteins, DNA and RNA and is commonly used in conjunction with other biophysical techniques to link thermodynamics, structure and function to fully characterize biopharmaceutical products. The development of sophisticated, modulated temperature programs and high scan rates provided additional benefits over DSC while introduction of hyphenated thermal techniques provided a more insight view of solid-state properties along with thermal characterization. Researchers are of the opinion that DSC will retain its place at the forefront of the pharmaceutical and biopharmaceuticals thermal analytical sciences in coming years.\r\n\r\nKeywords: DSC, thermal methods, pharmaceutical, biopharmaceutical
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